Stephen Dertinger, PhD
Director of Research, Litron Laboratories
Stephen Dertinger received his post-graduate training from the University of Rochester, Dept. Environmental Medicine. At the U of R, Stephen worked with Dr. Thomas Gasiewicz studying the role of AhR signaling on the toxicity of cigarette smoke. Since completing his Ph.D. Stephen has served as Director of Research, Litron Laboratories. During this time, he has overseen the development of high throughput in vitro and in vivo cytogenetic damage assays, most notably automated procedures for scoring micronuclei in mammalian cell culture and also blood reticulocytes. These methods have been developed into simple to use kits that are commercially available under the trade name MicroFlow, and they are used throughout the world by industry and government laboratories to assess chemicals for genotoxic potential. More recently, Stephen’s research team developed in vitro and in vivo mutation assays based on the Pig-a gene (MutaFlow), and a multiplexed high information content in vitro assay that distinguishes between clastogenic and aneugenic modes of action (MultiFlow). Stephen has served on IWGT, ECVAM, and OECD expert working groups. Through these committees, Stephen has helped shape the regulatory requirements for genotoxicity assays in the U.S. and abroad. Honors include: NIH Tibbett’s Award recipient; Rochester Intellectual Property Law Association Distinguished Inventor of the Year; EMGS Alexander Hollaender Award; GTA Excellence in Science Award.